Alterations to task positive and task negative networks during executive functioning in Mild Cognitive Impairment
| Autor: | Amy M. Jimenez, Stacy Schantz Wilkins, Gali H. Weissberger, Hannah Riskin-Jones, David L. Sultzer, Rebecca J. Melrose, Arpi S. Hasratian, Joseph Veliz |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Aging Neurodegenerative Neuropsychological Tests Alzheimer's Disease Prefrontal cortex lcsh:RC346-429 Task (project management) Executive Function 0302 clinical medicine 80 and over Cognitive impairment Default mode network Aged 80 and over Brain Mapping 05 social sciences Brain Regular Article Middle Aged Magnetic Resonance Imaging Mental Health Memory Short-Term Neurology Left prefrontal cortex lcsh:R858-859.7 Female Psychology Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics Basic Behavioral and Social Science behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences Memory Clinical Research Behavioral and Social Science Biological neural network Acquired Cognitive Impairment Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Cognitive Dysfunction lcsh:Neurology. Diseases of the nervous system Aged Neural correlates of consciousness Working memory Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Mild cognitive impairment Brain Disorders Short-Term Dementia Neurology (clinical) Nerve Net Executive functioning Neuroscience human activities 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 19, Iss, Pp 970-981 (2018) |
| ISSN: | 2213-1582 |
| Popis: | Poor executive functioning increases risk of decline in Mild Cognitive Impairment (MCI). Executive functioning can be conceptualized within the framework of working memory. While some components are responsible for maintaining representations in working memory, the central executive is involved in the manipulation of information and creation of new representations. We aimed to examine the neural correlates of these components of working memory using a maintenance working memory and visuospatial reasoning task. Twenty-five patients with amnestic MCI and 19 elderly controls (EC) completed functional MRI during reasoning and maintenance working memory tasks. In MCI, maintenance working memory was associated with hypoactivation of right frontoparietal regions and hyperactivation of left prefrontal cortex, coupled with attenuation of default mode network (DMN) relative to EC. During reasoning, MCI showed hypoactivation of parietal regions, coupled with attenuation of anterior DMN and increased deactivation of posterior DMN relative to EC. Comparing the reasoning task to the maintenance working memory task yields the central executive. In MCI, the central executive showed hypoactivation of right parietal lobe and increased deactivation of posterior DMN compared to EC. Consistent with prior work on executive functioning, MCI show different neural circuitry during visuospatial reasoning, including changes to both task positive frontoparietal regions, as well as to deactivation patterns within the DMN. Both hyperactivation of task positive networks and increased deactivation of DMN may be compensatory. Highlights • MCI show changes to task positive & negative networks during executive functioning. • MCI show hypoactivation of parietal cortex & attenuation of medial PFC deactivation. • Hypoactivation occurs in regions vulnerable to AD pathology. • MCI show hyperactivation of left PFC & more deactivation of posterior DMN. • These activity increases correlate with stronger cognition and may be compensatory. |
| Databáze: | OpenAIRE |
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