Effects of AT1 Receptor Antagonist Losartan on sICAM-1 and TNF-a Levels in Uncomplicated Hypertensive Patients
| Autor: | Maurizio Cinquegrani, Domenica Altavilla, Salvatore Campo, M.A. Sardo, Antonino Saitta, Maria Castaldo, Giuseppe M. Campo, Luisa Fontana, Michele Bonaiuto |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Diastole Uncomplicated Hypertensive Patients 030204 cardiovascular system & hematology Essential hypertension Placebo Losartan 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Internal medicine medicine Humans Single-Blind Method 030212 general & internal medicine Antihypertensive Agents Angiotensin II receptor type 1 Tumor Necrosis Factor-alpha business.industry Antagonist Middle Aged sICAM-1 Intercellular Adhesion Molecule-1 medicine.disease TNF-α Endocrinology Blood pressure Hypertension Female Cardiology and Cardiovascular Medicine business Angiotensin II Type 1 Receptor Blockers medicine.drug |
| Zdroj: | Angiology. 55:195-203 |
| ISSN: | 1940-1574 0003-3197 |
| Popis: | This study was designed to determine whether the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and tumor necrosis factor-alpha (TNF-alpha) were elevated in subjects with uncomplicated hypertension who presented with no other risk factors or evidence of athero-sclerosis. The effects of administration of an angiotensin type-1 antagonist (losartan) on the serum concentrations of these molecules were also examined. Twenty hypertensive (HT) subjects (12 men and 8 women, mean age 49.1 +/-7.2 years) without other risk factors or cardiovascular disease received placebo for 4 weeks. The patients were then treated with losartan (50 mg/day) for 24 weeks. After 4, 12, and 24 weeks of losartan treatment, sICAM-1 and TNF-alpha levels were measured. The same parameters were measured in 20 normotensive control subjects (C), matched for sex and age. HT had sICAM-1 and TNF-alpha basal values higher than C (respectively 351.7 +/-97.4 vs 201.6 +/-32.3 ng/mL, p |
| Databáze: | OpenAIRE |
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