Cypermethrin inhibits interleukin-6-induced androgen receptor transactivation through signal transducer and activator of transcription 3
| Autor: | Qi Wang, Ji-Long Zhou, Li-Chun Xu, Gang Chen, Mei-Rong Zhang, Xing Ge, Hui Wang, Heng-Xue Wang, Zhen Ding, Qiang Ju, Jin-Peng Zhang, Qiao-Mei Shi, Meng-Xue Li |
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| Rok vydání: | 2017 |
| Předmět: |
STAT3 Transcription Factor
Transcriptional Activation 0301 basic medicine Insecticides Health Toxicology and Mutagenesis Toxicology Cell Line Cypermethrin 03 medical and health sciences Transactivation chemistry.chemical_compound 0302 clinical medicine Western blot Pyrethrins medicine Animals Humans Phosphorylation Interleukin 6 STAT3 biology medicine.diagnostic_test Interleukin-6 Molecular biology Androgen receptor 030104 developmental biology chemistry Receptors Androgen 030220 oncology & carcinogenesis STAT protein biology.protein |
| Zdroj: | Toxicology Mechanisms and Methods. 27:717-722 |
| ISSN: | 1537-6524 1537-6516 |
| DOI: | 10.1080/15376516.2017.1351505 |
| Popis: | The insecticide cypermethrin has been considered as an endocrine-disrupting chemicals (EDCs) with anti-androgenic activity by interfering with interleukin-6 (IL-6) – induced ligand-independent AR signaling. The purpose of this study was to clarify whether the signal transducer and activator of transcription 3 (STAT3) was involved in the antagonism effect of cypermethrin. In this study, the Western blot was to test the level of STAT3 phosphorylation and the mammalian two-hybrid assay was developed to assess the AR–STAT3 interaction. The date showed that IL-6 increased the phosphorylation level of STAT3 and enhanced the AR–STAT3 interaction. Cypermethrin did not affect the phosphorylation level of STAT3 induced by IL-6, while suppressed the AR-STAT3 interaction induced by IL-6 significantly at the concentration of 10−5 M (p |
| Databáze: | OpenAIRE |
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