Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors
| Autor: | Kam Tat Leung, Lisa Au, Xiaolin Tian, Vincent Mok, Brian Yiu, Lin Shi, Winnie C.W. Chu, Alexander Y.L. Lau, Marco Duering, Haiqing Song, Ho Ko, Jill Abrigo, Yumi Tang, Kai Wang, Bonnie Y.K. Lam, Qun Xu, Yuhua Fan, Lei Zhao, Adrian Wong, J. Matthijs Biesbroek, Jian Hui Fu |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Mediation (statistics) Clinical Neurology Neuroimaging Vascular risk lcsh:Geriatrics lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Internal medicine Age related medicine Association (psychology) Stroke lcsh:Neurology. Diseases of the nervous system 030304 developmental biology 0303 health sciences Community subjects business.industry Cognition medicine.disease Regression Small vessel disease lcsh:RC952-954.6 Psychiatry and Mental health Diffusion tensor imaging Neurology (clinical) business Processing speed Peak width of skeletonized mean diffusivity 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 721-729 (2019) Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11, 721. Elsevier BV Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring |
| ISSN: | 2352-8729 |
| DOI: | 10.1016/j.dadm.2019.09.003 |
| Popis: | Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes. Results PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations. |
| Databáze: | OpenAIRE |
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