Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties

Autor:	Ping Sun, Jing Wang, Khadija S. Khan, Weiqin Yang, Billy Wai-Lung Ng, Nikita Ilment, Matthes Zessin, Emre F. Bülbül, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred Sze-Lok Cheng, Wolfgang Sippl
Rok vydání:	2022
Předmět:	Histone Deacetylase Inhibitors Repressor Proteins Mice Inbred C57BL Mice Hydrazines Drug Discovery Animals Molecular Medicine Histone Deacetylases
Zdroj:	Journal of Medicinal Chemistry. 65:16313-16337
ISSN:	1520-4804 0022-2623
DOI:	10.1021/acs.jmedchem.2c01132
Popis:	Histone deacetylases (HDACs) are epigenetic regulators and additionally control the activity of non-histone substrates. We recently demonstrated that inhibition of HDAC8 overexpressed in various of cancers reduces hepatocellular carcinoma tumorigenicity in a T cell-dependent manner. Here, we present alkylated hydrazide-based class I HDAC inhibitors in which the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c985e4087f311b0e6b58dd9531d9764 https://doi.org/10.1021/acs.jmedchem.2c01132 Zobrazit plný text záznamu