S100-Beta, melanoma-inhibiting activity, and lactate dehydrogenase discriminate progressive from nonprogressive American Joint Committee on Cancer stage IV melanoma
| Autor: | Martin Deichmann, Andreas Jäckel, Axel Benner, Karen Uhl, Michael Bock, Helmut Näher, Volker Waldmann |
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| Rok vydání: | 1999 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Pathology Skin Neoplasms Blood Sedimentation Sensitivity and Specificity chemistry.chemical_compound Predictive Value of Tests Reference Values Lactate dehydrogenase Internal medicine Biomarkers Tumor Medicine Humans Melanoma Aged Neoplasm Staging Extracellular Matrix Proteins medicine.diagnostic_test L-Lactate Dehydrogenase business.industry Melanoma inhibitory activity S100 Proteins Cancer Venous blood Middle Aged medicine.disease Neoplasm Proteins Logistic Models chemistry ROC Curve Predictive value of tests Erythrocyte sedimentation rate Area Under Curve Disease Progression Female business Progressive disease |
| Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 17(6) |
| ISSN: | 0732-183X |
| Popis: | PURPOSE: Monitoring advanced malignant melanoma, serum levels of S100-beta (S100β) and melanoma-inhibiting activity (MIA) were assessed for the ability to discriminate progressive from nonprogressive disease. S100β and MIA were supposed to be superior to conventional variables, such as lactate dehydrogenase (LDH) level. PATIENTS AND METHODS: Seventy-one patients with stage IV malignant melanoma according to the criteria of the American Joint Committee on Cancer (AJCC) were included in the study. Results of restaging examinations were used as an independent reference standard for diagnosing progressive disease, and S100β, MIA, LDH level, and erythrocyte sedimentation rate (ESR) were determined in venous blood just before restaging. Sensitivities and specificities of the parameters were calculated by logistic regression analysis. Discrimination ability was assessed by Somers' Dxy rank correlation and the area under the receiver-operating characteristic curve (ROC-AUC). RESULTS: All tested serum parameters were significantly elevated in patients with progressive disease. The highest sensitivities according to the established thresholds were found for S100β and MIA (91% and 88%, respectively). LDH had the highest specificity (92%). ESR was dropped from the analysis because of low specificity. In calculating Somers' Dxy and ROC-AUC values, S100β, MIA, and LDH showed high discrimination ability. By multiple logistic regression, LDH was identified to be the only statistically significant marker for progressive disease. S100β and MIA did not provide additional significant information because of their high correlation with LDH with respect to clinical outcome. CONCLUSION: Elevated serum levels of S100β, MIA, and LDH indicate current disease progression in AJCC stage IV melanoma. LDH was the most relevant overall parameter. |
| Databáze: | OpenAIRE |
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