Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma
| Autor: | John Coyne, Jennifer Varley, Martin Harris, M Tariq, Claire L Attwooll, Nicholas Telford |
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| Rok vydání: | 1999 |
| Předmět: |
Receptors
Steroid Cancer Research Molecular Sequence Data Orphan Nuclear Receptor Gene Chondrosarcoma Nerve Tissue Proteins Chromosomal translocation Biology Translocation Genetic Myxoid chondrosarcoma Fusion gene Transactivation Genetics medicine Humans Amino Acid Sequence Molecular Biology TATA-Binding Protein Associated Factors Receptors Thyroid Hormone Base Sequence Reverse Transcriptase Polymerase Chain Reaction Nuclear Proteins Extraskeletal Myxoid Chondrosarcoma medicine.disease Fusion protein Molecular biology Artificial Gene Fusion DNA-Binding Proteins Chromosome abnormality Chromosomes Human Pair 9 Chromosomes Human Pair 17 Transcription Factors |
| Zdroj: | Oncogene. 18:7599-7601 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1203156 |
| Popis: | A proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. We report here a case of EMC with a t(9;17)(q22;q11.2) as the sole chromosome abnormality. We have determined that the translocation results in the fusion of the entire coding region of CHN to the N-terminal transactivation domain of RBP56/hTAFII68. This is the first report of a translocation involving RBP56/hTAFII 68, a protein with sequence homology to both EWS and TLS/FUS. The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour. |
| Databáze: | OpenAIRE |
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