SARS‐CoV‐2, COVID‐19, skin and immunology – What do we know so far?
| Autor: | Charlotte Brüggen, Mirjam C. Naegeli, Beatriz Cabanillas, Alba Catala, Christina Galvan, Isabel Kolm-Djamei, Natalijia Novak, Wenming Peng, Peter Schmid-Grendelmeier |
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| Přispěvatelé: | University of Zurich, Novak, Natalijia |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine myalgia skin Immunology 610 Medicine & health Review virus Disease medicine.disease_cause Skin Diseases Asymptomatic 03 medical and health sciences 0302 clinical medicine Humans Medicine Immunology and Allergy Respiratory system Coronavirus 2403 Immunology SARS-CoV-2 business.industry COVID-19 10177 Dermatology Clinic allergy medicine.disease Diarrhea 030104 developmental biology 030228 respiratory system Respiratory failure 2723 Immunology and Allergy Female Angiotensin-Converting Enzyme 2 medicine.symptom business Vasculitis drug hypersensitivity |
| Zdroj: | Allergy |
| Popis: | The pandemic condition Coronavirus‐disease (COVID‐19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can take asymptomatic, mild, moderate, and severe courses. COVID‐19 affects primarily the respiratory airways leading to dry cough, fever, myalgia, headache, fatigue, and diarrhea and can end up in interstitial pneumonia and severe respiratory failure. Reports about the manifestation of various skin lesions and lesions of the vascular system in some subgroups of SARS‐CoV‐2 positive patients as such features outside the respiratory sphere, are rapidly emerging. Vesicular, urticarial and maculopapular eruptions as well as livedo, necrosis and other vasculitis forms have been reported most frequently in association with SARS‐CoV‐2 infection. In order to update information gained, we provide a systematic overview of the skin lesions described in COVID‐19 patients, discuss potential causative factors and describe differential diagnostic evaluations. Moreover, we summarize current knowledge about immunologic, clinical and histologic features of virus‐ as well as drug‐induced lesions of the skin and changes to the vascular system in order to transfer this knowledge to potential mechanisms induced by SARS‐CoV‐2. |
| Databáze: | OpenAIRE |
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