Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses
| Autor: | David S. Hsu, Yasuhide Miyamoto, Aziz Sancar, Martha Hotz Vitaterna, Joseph S. Takahashi, Claude Petit, Randy J. Thresher, Oliver Smithies, Aleksey Kazantsev, Christopher P. Selby, Lale Dawut |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
animal structures Light Period (gene) Cell Cycle Proteins Motor Activity Biology Receptors G-Protein-Coupled Mice Cryptochrome Animals Drosophila Proteins Arabidopsis thaliana Photopigment Circadian rhythm Eye Proteins In Situ Hybridization Genetics Multidisciplinary Flavoproteins Suprachiasmatic nucleus Nuclear Proteins Period Circadian Proteins biology.organism_classification Circadian Rhythm Cell biology Cryptochromes Mice Inbred C57BL Gene Expression Regulation Light effects on circadian rhythm Gene Targeting Mutation Female Photoreceptor Cells Invertebrate Suprachiasmatic Nucleus sense organs Photoreceptor Cells Vertebrate |
| Zdroj: | Science. 282:1490-1494 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Cryptochromes are photoactive pigments in the eye that have been proposed to function as circadian photopigments. Mice lacking the cryptochrome 2 blue-light photoreceptor gene ( mCry2 ) were tested for circadian clock-related functions. The mutant mice had a lower sensitivity to acute light induction of mPer1 in the suprachiasmatic nucleus (SCN) but exhibited normal circadian oscillations of mPer1 and mCry1 messenger RNA in the SCN. Behaviorally, the mutants had an intrinsic circadian period about 1 hour longer than normal and exhibited high-amplitude phase shifts in response to light pulses administered at circadian time 17. These data are consistent with the hypothesis that CRY2 protein modulates circadian responses in mice and suggest that cryptochromes have a role in circadian photoreception in mammals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|