The role of circulating miR-146a in patients with rheumatoid arthritis treated by Tripterygium wilfordii Hook F
| Autor: | Xue-Dan Zhang, Ya-Bing Wu, Ying Chen, Zhen-Zhou Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Risk rheumatoid arthritis Tripterygium Arthritis Observational Study Severity of Illness Index law.invention Pathogenesis Arthritis Rheumatoid 03 medical and health sciences law medicine Humans circulating Autoimmune disease Tripterygium wilfordii Hook F biology business.industry General Medicine Middle Aged medicine.disease biology.organism_classification Prognosis miR-146a MicroRNAs 030104 developmental biology Treatment Outcome ROC Curve Rheumatoid arthritis Antirheumatic Agents Area Under Curve Immunology Etiology Leukocytes Mononuclear Female Tripterygium wilfordii Phytotherapy business disease activity Biomarkers Drugs Chinese Herbal Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Rheumatoid arthritis (RA) is polygenic autoimmune disease with unclear etiology. MicroRNAs (miRNAs) play a critical role in the pathogenesis of RA. The objective of this study was to evaluate the role of miR-146a in patients with RA receiving Tripterygium wilfordii Hook F (TwHF) treatment. In total, 69 patients with RA and 69 healthy controls (HC) were included in the study, and patients with RA received TwHF treatment for 24 weeks. Blood samples were collected from RA patients and HC, and peripheral blood mononuclear cells (PBMCs) were isolated. Expression of miR-146a was analyzed in RA patients (baseline, 12 weeks and 24 weeks) and HC. Circulating miR-146a expression was markedly increased in patients with RA compared with healthy controls (P |
| Databáze: | OpenAIRE |
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