In vitro antifungal susceptibility testing of fungi in patients with onychomycosis
| Autor: | Manar Ibrahim Abd Elhameed, Ramadan A Saleh, Mohammed Abu El-Hamd, Mona Fattouh Mohamed Shalaby |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antifungal Agents
Itraconazole Dermatology Naphthalenes Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Candidal onychomycosis Onychomycosis Humans Medicine Trichophyton Terbinafine biology business.industry General Medicine Griseofulvin biology.organism_classification medicine.disease chemistry 030220 oncology & carcinogenesis Penicillium business Microsporum Fluconazole medicine.drug |
| Zdroj: | Dermatologic Therapy. 33 |
| ISSN: | 1529-8019 1396-0296 |
| DOI: | 10.1111/dth.13429 |
| Popis: | Onychomycosis is the most common nail disorder. To examine in vitro antifungal susceptibility of fungi among onychomycosis patients. The study included 68 patients with onychomycosis. Nail specimens were cultured on Sabouraud dextrose agar and Dermasel agar base-media. Isolated fungi were subjected to antifungal susceptibility tests against terbinafine, itraconazole, fluconazole, and griseofulvin. Candida species (Candida spp.) were detected in 32.4% of the cases of candidal onychomycosis (n = 37), 23.5% of the cases of distal and lateral subungual onychomycosis (n = 17), and 21.4% of the cases of total dystrophic onychomycosis (n = 14). Candida spp. were sensitive to fluconazole in 73.5%, itraconazole in 58.8%, and terbinafine in 5.9% of the cases. Aspergillus spp. were sensitive to itraconazole in all cases, and terbinafine in 87.5% of cases. Penicillium spp. were sensitive to itraconazole and terbinafine in 88.9% and 77.8% of cases, respectively. Trichophyton spp. were sensitive to terbinafine and resistant to itraconazole. Microsporum spp. were sensitive to itraconazole and resistance to terbinafine. All isolated fungi were resistant to griseofulvin. An increasing proportion of Candida spp. was observed among patients with different clinical varieties of onychomycosis. Candida spp. were highly sensitive to fluconazole and a lesser extent to itraconazole. |
| Databáze: | OpenAIRE |
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