Oncological benefits of postoperative radiotherapy in node-negative early stage cancer of the oral cavity with isolated perineural invasion
| Autor: | Ajay K. Dewan, Himanshu Shukla, Suhas Kodasoge Rajappa, M. Venkatasubramaniyan, M. Agarwal, Ghanashyam Mandal, Rajeev Kumar, Dharma Ram, A. Dubey |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Postoperative radiotherapy Perineural invasion Oral cavity 03 medical and health sciences Early-stage cancer 0302 clinical medicine Adjuvant therapy Medicine Humans Neoplasm Invasiveness Postoperative Period 030223 otorhinolaryngology Aged Neoplasm Staging Retrospective Studies business.industry Cancer Middle Aged medicine.disease Prognosis Surgery Radiation therapy Otorhinolaryngology 030220 oncology & carcinogenesis Lymphatic Metastasis Carcinoma Squamous Cell Female Mouth Neoplasms Radiotherapy Adjuvant Oral Surgery Neoplasm Recurrence Local business Adjuvant |
| Zdroj: | The British journal of oralmaxillofacial surgery. 57(5) |
| ISSN: | 1532-1940 |
| Popis: | Perineural invasion has been widely regarded as a poor prognostic factor in cancer of the oral cavity, but adjuvant treatment based only on this is still debatable. We have made an effort to address the question in a retrospective analysis of data from 2009–15 of patients with early node-negative cancers of the oral cavity. Patients with perineural invasion were divided into those who were treated with radiotherapy and those who were not. The records of a total of 169 patients were analysed, and 118 were given adjuvant radiotherapy and 51 were not. The median (range) duration of follow up was 45 (26–86) months. Of 169 patients, 47 (28%) developed recurrence, 28 in the treated, and 19 in the untreated, group. There was a significant disease-free survival benefit for adjuvant treatment (p = 0.047) but no overall survival benefit (p = 0.54). We conclude that adjuvant radiotherapy should be considered for patients with perineural invasion, even in early cancers of the oral cavity. |
| Databáze: | OpenAIRE |
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