The endoplasmic reticulum and mitochondria as elements of the mechanism of intracellular signaling in the nerve cell

Autor:	A V Shmigol, E. P. Kostyuk, Nana Voitenko, N. V. Svichar, P. G. Kostyuk
Rok vydání:	2000
Předmět:	Neurons Membrane potential General Neuroscience Endoplasmic reticulum STIM1 Cell Communication Mitochondrion Biology Endoplasmic Reticulum Transmembrane protein Mitochondria Rats Cell biology Mice Cytosol Animals Humans Calcium Signaling Intracellular Calcium signaling
Zdroj:	Scopus-Elsevier
ISSN:	1573-899X 0097-0549
DOI:	10.1007/bf02461387
Popis:	Experimental data obtained in our laboratory from studies of intracellular signals arising within nerve cells during excitation are summarized. Measurements of transmembrane ion currents in conditions of fixed membrane potential and intracellular free Ca ion concentrations, using fluorescent probes, yielded the time and spatial characteristics of transient elevations in the Ca concentration (the "calcium signal") in various types of mouse and rat neurons. These studies showed that intracellular structures-the endoplasmic reticulum and mitochondria-had significant roles in forming these signals; these structures can take up Ca from the cytosol and liberate Ca into the cytosol; the contribution of these processes was extremely variable, depending on the internal organization of different functional types of neurons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9383f16add9fdb25f0d2d3aed67888 https://doi.org/10.1007/bf02461387 Zobrazit plný text záznamu Full text from SpringerLink