Adult sacrococcygeal teratoma: a retrospective study over eight years at a single institution
| Autor: | Jianjiang Lin, Jing-peng Liu, Weiqin Jiang, Xiaofei Cheng, Xiangming Xu, Feng Zhao, Weixiang Zhong, Xiao-kai Yu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Complete resection Article General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics Single institution Aged Pain Measurement Retrospective Studies Surgical approach General Veterinary Adult patients medicine.diagnostic_test Sacrococcygeal Region business.industry Teratoma Margins of Excision Retrospective cohort study Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Treatment Outcome 030104 developmental biology 030220 oncology & carcinogenesis Female Radiology Neoplasm Recurrence Local Tomography X-Ray Computed Sacrococcygeal teratoma business |
| Zdroj: | Journal of Zhejiang University-SCIENCE B. 20:670-678 |
| ISSN: | 1862-1783 1673-1581 |
| Popis: | Objective: To determine the clinical, imaging, and histological features, and surgical resection modalities and outcomes of adult sacrococcygeal teratoma (SCT). Methods: Adult patients with histopathologically diagnosed SCT were enrolled in our hospital between August 2010 and August 2018. Each patient’s characteristics and clinical information were reviewed. Results: There were 8 patients in the study (2 males, 6 females) with a median age of 34 years (range, 18–67 years). The time to clinical symptoms was 14 d to 35 years, with a median time of 4 years. Six patients presented with symptoms of sacrococcygeal pain, and four with signs of sacrococcygeal mass and ulceration in the sacrococcygeal region. Six patients were evaluated using a combination of computed tomography (CT) and magnetic resonance imaging (MRI). All patients showed a presacral tumor with heterogeneous intensity on CT images. All patients underwent surgical treatment, including 6 parasacral, 1 transabdominal, and 1 combined anterior-posterior surgery cases. Seven patients were histopathologically diagnosed with benign mature SCT, and have shown no recurrence. One patient had malignant SCT, with recurrence at 84 months after surgery. After a second surgery, the patient had no recurrence within 6 months follow-up after re-resection. Conclusions: Our retrospective study demonstrated: (1) adult SCT is difficult to diagnose because of a lack of typical clinical symptoms and signs; (2) a combination of CT and MRI examination is beneficial for preoperative diagnosis; (3) the choice of surgical approach and surgical resection modality depends on the size, location, and components of the tumor, which can be defined from preoperative CT and MRI evaluation; (4) most adult SCTs are benign; the surgical outcome for the malignant SCT patient was good after complete resection. Even for the patient with recurrent malignant SCT, the surgical outcome was good after re-resection. |
| Databáze: | OpenAIRE |
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