Influence of food on the pharmacokinetics of quinapril and its active diacid metabolite, CI-928
| Autor: | J. R. Latts, A. M. Horvath, Wayne A. Colburn, Allen J. Sedman, J. J. Ferry |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Chromatography Gas Metabolite Angiotensin-Converting Enzyme Inhibitors Urine Pharmacology chemistry.chemical_compound Pharmacokinetics Oral administration Internal medicine Tetrahydroisoquinolines medicine Humans Pharmacology (medical) Volunteer Active metabolite Quinapril Middle Aged Isoquinolines Crossover study Endocrinology chemistry Food medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 27(5) |
| ISSN: | 0091-2700 |
| Popis: | A randomized two-way crossover study was conducted in 12 healthy volunteers to assess the effect of food on the pharmacokinetics of quinapril (CI-906) and its active metabolite, CI-928, after quinapril dosing. Forty-milligram oral quinapril doses were administered in a fasted or a fed state with a one-week washout period between treatments. No significant treatment differences were observed in quinapril and CI-928 values for maximum plasma concentration, area under the plasma concentration-time curve, or percentage of dose excreted in the urine. Small but significant increases of less than 0.5 hour in quinapril and CI-928 tmax values were observed after consumption of food. The pharmacokinetic profiles of quinapril and CI-928 were not significantly altered by the administration of food. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text