Cardiac Amyloidosis for the Primary Care Provider: A Practical Review to Promote Earlier Recognition of Disease
| Autor: | Srilakshmi Vallabhaneni, Ronald J. Krone, Joshua D. Mitchell, Kathleen W. Zhang, Daniel J. Lenihan, Jose Alvarez-Cardona |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Heart Diseases Disease Primary care 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Epidemiology medicine Humans 030212 general & internal medicine Symptom onset Intensive care medicine biology Primary Health Care business.industry Amyloidosis General Medicine medicine.disease Transthyretin Early Diagnosis Cardiac amyloidosis Heart failure biology.protein business |
| Zdroj: | The American journal of medicine. 134(5) |
| ISSN: | 1555-7162 |
| Popis: | Cardiac amyloidosis is increasingly recognized as an underdiagnosed cause of heart failure. Diagnostic delays of up to 3 years from symptom onset may occur, and patients may be evaluated by more than 5 specialists prior to receiving the correct diagnosis. Newly available therapies improve clinical outcomes by preventing amyloid fibril deposition and are usually more effective in early stages of disease, making early diagnosis essential. Better awareness among primary care providers of the clinical presentation and modern treatment landscape is essential to improve timely diagnosis and early treatment of this disease. In this review, we provide practical guidance on the epidemiology, clinical manifestations, diagnostic evaluation, and treatment of transthyretin and light chain cardiac amyloidosis to promote earlier disease recognition among primary care providers. |
| Databáze: | OpenAIRE |
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