The long-term effects of metoprolol and epanolol on tissue-type plasminogen activator and plasminogen activator inhibitor 1 in patients with ischaemic heart disease
| Autor: | R. A. Riemersma, I. R. MacGregor, N. A. Boon, A. M. Perrie, F. Stenhouse, K. G. M. M. Alberti, Robert A. Wright |
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| Rok vydání: | 1994 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Nifedipine medicine.medical_treatment Adrenergic beta-Antagonists Benzeneacetamides Blood Pressure Pharmacology Angina Pectoris Propanolamines chemistry.chemical_compound Double-Blind Method Risk Factors Internal medicine Fibrinolysis Plasminogen Activator Inhibitor 1 medicine Humans Insulin Pharmacology (medical) Metoprolol T-plasminogen activator business.industry Antagonist General Medicine Lipids Endocrinology chemistry Plasminogen activator inhibitor-1 Tissue Plasminogen Activator Epanolol business Plasminogen activator medicine.drug |
| Zdroj: | European journal of clinical pharmacology. 46(3) |
| ISSN: | 0031-6970 |
| Popis: | This double-blind, randomized parallel group study investigated the effect of 6 months beta-adrenoceptor antagonist therapy with either metoprolol (beta 1-selective without intrinsic sympathomimetic activity [ISA]) or epanolol (beta 1-selective with ISA) on markers of endogenous fibrinolysis in 20 patients with chronic stable angina receiving concurrent treatment with nifedipine. Neither drug had an effect on tissue-type plasminogen activator or plasminogen activator inhibitor type 1 (PAI-1). A significant correlation between fasting insulin and PAI-1 has previously been described and was confirmed in this study. The group treated with metoprolol showed a significant rise in fasting insulin after 6 months with no change in PAI-1. This suggests that the previously described link between these two may not be causal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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