Assessment of mineral and bone biomarkers highlights a high frequency of hypercalciuria in asymptomatic healthy teenagers
| Autor: | Bruno Ranchin, Laurence Dubourg, Christelle Roger, Justine Bacchetta, Tiphanie Ginhoux, Delphine Bernoux |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Hypercalciuria chemistry.chemical_element Parathyroid hormone Renal function Calcium Bone and Bones Phosphates 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Reference Values 030225 pediatrics Internal medicine Medicine Humans 030212 general & internal medicine Vitamin D Child Creatinine biology business.industry General Medicine medicine.disease Urinary calcium Fibroblast Growth Factor-23 Endocrinology Cross-Sectional Studies chemistry Pediatrics Perinatology and Child Health Osteocalcin biology.protein Sclerostin Female business Biomarkers |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992)REFERENCES. 108(12) |
| ISSN: | 1651-2227 |
| Popis: | Aim Assessment of mineral metabolism is complex in paediatrics. Methods We assessed the evolution of the main mineral and bone biomarkers (total/bone alkaline phosphatase ALP/BAP, β-crosslaps, osteocalcin, sclerostin, C-terminal and intact FGF23) in 100 healthy teenagers (10-18 years, 50 boys). Results At a mean age of 13.7 ± 2.2 years, phosphatemia, tubular phosphate reabsorption, ALP and BAP significantly decreased along puberty in both genders, whilst parathyroid hormone (PTH), 25-vitamin D (25D), FGF23, plasma calcium and urinary calcium were not modified. In girls, osteocalcin, β-crosslaps and sclerostin significantly decreased at the end of puberty. Calciuria above the crystallisation threshold (>3.8 mmol/L) and urinary calcium/creatinine ratio >0.7 mmol/mmol were found in 39% and 6% of subjects, respectively. Multivariable analyses showed that renal function and PTH were significant predictors of calciuria and urinary calcium/creatinine, whilst 25D remained a predictor only of urinary calcium/creatinine ratio. Conclusion Using the most recent assays, this study provides data for mineral/bone biomarkers across puberty and highlights the risk of hyper-calciuria in apparent asymptomatic healthy teenagers, not related to calcium intake but rather to 25D. Future studies are required to dissect the underlying mechanisms increasing calciuria and prevent nephrolithiasis as early as during childhood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text