Fat fractions from high-resolution 3D radial Dixon MRI for predicting metastatic axillary lymph nodes in breast cancer patients

Autor: Erik Morre Pedersen, Kim Sivesgaard, Thomas Winther Buus, Peer Christiansen, Anders Bonde Jensen, Tanja Linde Fris
Jazyk: angličtina
Rok vydání: 2020
Předmět:
ROI
region of interest
030218 nuclear medicine & medical imaging
FF
fat fraction
0302 clinical medicine
ADC
apparent diffusion coefficient
DWI
diffusion-weighted imaging
SLNB
sentinel lymph node biopsy
ALND
axillary lymph node dissection
Lymph node
TE
echo time
medicine.diagnostic_test
US
ultrasonography
ROC
receiver operating characteristics
F
fat
TR
repetition time
medicine.anatomical_structure
NPV
negative predictive value
SPAIR
spectral attenuated inversion recovery
030220 oncology & carcinogenesis
IDC
invasive ductal carcinoma
Lymph
IP
in-phase
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty
Axillary lymph nodes
lcsh:R895-920
Lymphatic metastasis
Article
AUC
area under the ROC curve
03 medical and health sciences
Breast cancer
Magnetic resonance imaging
STIR
short tau inversion recovery
medicine
Radiology
Nuclear Medicine and imaging
ILC
invasive lobular carcinoma
Receiver operating characteristic
business.industry
W
water
medicine.disease
PPV
positive predictive value
Axilla
OP
opposed-phase
LN
lymph node
Histopathology
Breast neoplasms
Nuclear medicine
business
Zdroj: Buus, T W, Sivesgaard, K, Fris, T L, Christiansen, P M, Jensen, A B & Pedersen, E M 2020, ' Fat fractions from high-resolution 3D radial Dixon MRI for predicting metastatic axillary lymph nodes in breast cancer patients ', European journal of radiology open, vol. 7, 100284 . https://doi.org/10.1016/j.ejro.2020.100284
European Journal of Radiology Open, Vol 7, Iss, Pp 100284-(2020)
European Journal of Radiology Open
DOI: 10.1016/j.ejro.2020.100284
Popis: Highlights • High-Resolution 3D radial Dixon MRI allows for the creation of quantitative fat fraction images. • Lymph node fat fractions improves diagnostic performance of MRI to detect axillary lymph node metastases. • Lymph node fat fractions are a promising quantitative indicator of metastases in axillary lymph nodes.
Purpose To assess diagnostic performance of fat fractions (FF) from high-resolution 3D radial Dixon MRI for differentiating metastatic and non-metastatic axillary lymph nodes in breast cancer patients. Method High-resolution 3D radial Dixon MRI was prospectively performed on 1.5 T in 70 biopsy-verified breast cancer patients. 35 patients were available for analysis with histopathologic and imaging data. FF images were calculated as fat / in-phase. Two radiologists measured lymph node FF and assessed morphological features in one ipsilateral and one contralateral lymph node in consensus. Diagnostic performance of lymph node FF and morphological criteria were compared using histopathology as reference. Results 22 patients had metastatic axillary lymph nodes. Mean lymph node FF were 0.20 ± 0.073, 0.31 ± 0.079, and 0.34 ± 0.15 (metastatic, non-metastatic ipsi- and non-metastatic contralateral lymph nodes, respectively). Metastatic lymph node FF were significantly lower than non-metastatic ipsi- (p
Databáze: OpenAIRE
Externí odkaz: