Antimicrobial and Cytotoxic Activities of Synthetically Derived Tambjamines C and E - J, BE-18591, and a Related Alkaloid from the Marine Bacterium Pseudoalteromonas tunicata
| Autor: | Mary J. Garson, David M. Pinkerton, Francisco W.A. Barros, Martin G. Banwell, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Naresh Kumar, Cláudia Pessoa |
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| Rok vydání: | 2010 |
| Předmět: |
Erythrocytes
Bioengineering Microbial Sensitivity Tests Biochemistry Microbiology Mice chemistry.chemical_compound Alkaloids Anti-Infective Agents Cell Line Tumor Animals Humans Cytotoxic T cell Pyrroles Cytotoxicity Molecular Biology Antiinfective agent biology Cytotoxins Chemistry Alkaloid General Chemistry General Medicine Antimicrobial biology.organism_classification Pseudoalteromonas Molecular Medicine Tambjamine Drug Screening Assays Antitumor Pseudoalteromonas tunicata Bacteria |
| Zdroj: | ResearcherID |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.201000030 |
| Popis: | In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects. |
| Databáze: | OpenAIRE |
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