Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis
| Autor: | D.W. Motherwell, A Cormack, Kevin A. Deans, K. R. Paterson, B M Fisher, D St J O'Reilly, J Geddes |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac troponin Diabetic ketoacidosis Clinical Biochemistry Diabetic Ketoacidosis Cohort Studies Troponin T Internal medicine medicine Humans Prospective Studies Cystatin C Creatine Kinase Aged 3-Hydroxybutyric Acid biology business.industry Troponin I General Medicine Middle Aged Prognosis medicine.disease Cystatins Troponin Diabetes Mellitus Type 1 Treatment Outcome Endocrinology Echocardiography biology.protein Cardiology Female Ischaemic heart disease business Biomarkers |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 44:391-393 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1258/000456307780945750 |
| Popis: | Background: Elevated troponin concentrations may be observed in a wide spectrum of medical disorders in people without evidence of overt ischaemic heart disease. The prospective relationship between serum cardiac troponin I (cTnI) and diabetic ketoacidosis (DKA) has not been examined in adults. Methods: Forty patients (14 male and 26 female) with type 1 diabetes were recruited. cTnI, creatine kinase (CK), cystatin C and beta-hydroxybutyrate were measured on admission and at 24, 48 and 72 h post-admission. Daily electrocardiographs were also performed. Results: Four out of forty subjects presenting with DKA had an increase in cTnI (median (SD) 0.06 (0.31) μg/L). One of the subjects had multiple possible reasons for the elevated cTnI concentration. However, the other three subjects had no obvious precipitating factors. This cohort underwent echocardiography and thallium-201 scintigraphy, which revealed no abnormalities. Conclusions: Minor troponin elevations appear to occur in a small number of subjects with type 1 diabetes presenting with DKA. The clinical relevance of this at this stage remains unknown and further large-scale studies are suggested. |
| Databáze: | OpenAIRE |
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