Macular thickness as a predictor of loss of visual sensitivity in ethambutol-induced optic neuropathy
| Autor: | Bing Chen, Bing-jian Yang, Mo Yang, Qiu-hong Wang, Ai-di Zhang, Chunxia Peng, Shihui Wei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
genetic structures Nerve fiber layer ethambutol lcsh:RC346-429 macular thickness Optic neuropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience Optical coherence tomography ethambutol-induced optic neuropathy1 visual sensitivity Ophthalmology peripapillary retinal nerve fiber layer Medicine In patient nerve regeneration lcsh:Neurology. Diseases of the nervous system Ethambutol optical coherence tomography medicine.diagnostic_test business.industry Retinal medicine.disease Visual sensitivity eye diseases Surgery ethambutol-induced optic neuropathy neural regeneration medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Optic nerve sense organs business 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | Neural Regeneration Research Neural Regeneration Research, Vol 11, Iss 3, Pp 469-475 (2016) |
| ISSN: | 1876-7958 1673-5374 |
| Popis: | Ethambutol is a common cause of drug-related optic neuropathy. Prediction of the onset of ethambutol-induced optic neuropathy and consequent drug withdrawal may be an effective method to stop visual loss. Previous studies have shown that structural injury to the optic nerve occurred earlier than the damage to visual function. Therefore, we decided to detect structural biomarkers marking visual field loss in early stage ethambutol-induced optic neuropathy. The thickness of peripapillary retinal nerve fiber layer, macular thickness and visual sensitivity loss would be observed in 11 ethambutol-induced optic neuropathy patients (22 eyes) using optical coherence tomography. Twenty-four healthy age- and sex-matched participants (48 eyes) were used as controls. Results demonstrated that the temporal peripapillary retinal nerve fiber layer thickness and average macular thickness were thinner in patients with ethambutol-induced optic neuropathy compared with healthy controls. The average macular thickness was strongly positively correlated with central visual sensitivity loss (r (2) =0.878, P=0.000). These findings suggest that optical coherence tomography can be used to efficiently screen patients. Macular thickness loss could be a potential factor for predicting the onset of ethambutol-induced optic neuropathy. |
| Databáze: | OpenAIRE |
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