Effective nasal influenza vaccine delivery using chitosan
| Autor: | Robert C. Read, Simone Naylor, Jenny Bond, Christopher W. Potter, Inderjit Jabbal-Gill, Lisbeth Illum, A. N. Fisher, Roy Jennings |
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| Rok vydání: | 2004 |
| Předmět: |
Trivalent influenza vaccine
Adult Male Adolescent Influenza vaccine Chitin Vaccines Attenuated Immune system Drug Delivery Systems Antigen Medicine Humans Seroconversion Administration Intranasal Chitosan General Veterinary General Immunology and Microbiology business.industry Vaccination Public Health Environmental and Occupational Health Hemagglutination Inhibition Tests Middle Aged Virology Titer Infectious Diseases Influenza Vaccines Immunology Molecular Medicine Nasal administration Female business |
| Zdroj: | Vaccine. 23(35) |
| ISSN: | 0264-410X |
| Popis: | Nasal influenza vaccination may prove to be a good alternative to parenteral injection because of the enhancement of the mucosal immune response and the ease of vaccine administration. This study investigated the use of chitosan, a bioadhesive polymer, as a nasal delivery system with inactivated, subunit influenza vaccine. Subjects received nasally 15 or 7.5 microg of the standard inactivated trivalent influenza vaccine with chitosan or 15 microg of the same vaccine intramuscularly. Serum haemagglutination inhibition (HI) titres for all three vaccine components were measured prior to, and at time points up to 14 weeks after dosing. Serum HI titres following intranasal vaccination with the nasal chitosan-influenza vaccine met the criteria set by the Committee for Proprietary Medicinal Products in terms of seroprotection rate, seroconversion rate and mean fold increase of HI titre for at least one of the three antigens in the vaccination schedules used. These data show that nasal immunisation with chitosan plus trivalent inactivated influenza is a potentially effective, easily-administered form of vaccination. |
| Databáze: | OpenAIRE |
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