High protein-induced glomerular hypertrophy is vascular endothelial growth factor-dependent
| Autor: | Bieke F. Schrijvers, Ronald G. Tilton, Allan Flyvbjerg, Ruth Rasch |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty glomerular volume Renal glomerulus Kidney Glomerulus High-protein diet Mice Inbred Strains Endothelial Growth Factors Biology medicine.disease_cause urologic and male genital diseases Antibodies Muscle hypertrophy chemistry.chemical_compound Eating Mice kidney growth Internal medicine medicine high protein diet Animals Insulin-Like Growth Factor I mouse Kidney Lymphokines urogenital system Vascular Endothelial Growth Factors Body Weight Glomerulonephritis Heart Hypertrophy Organ Size Glomerular Hypertrophy medicine.disease VEGF Vascular endothelial growth factor Endocrinology medicine.anatomical_structure chemistry Liver Nephrology Female Kidney Diseases Dietary Proteins Kidney disease |
| Zdroj: | Kidney International. 61(5):1600-1604 |
| ISSN: | 0085-2538 |
| DOI: | 10.1046/j.1523-1755.2002.00310.x |
| Popis: | High protein-induced glomerular hypertrophy is vascular endothelial growth factor-dependent.BackgroundVarious growth factors and cytokines have been implicated in different forms of kidney enlargement such as renal growth following induction of diabetes, unilateral nephrectomy, and exposure to high protein diet. Vascular endothelial growth factor (VEGF) is essential for normal renal development and plays a role in diabetes-associated renal and glomerular enlargement.MethodsTo elucidate a possible role for VEGF in high protein-induced renal/glomerular enlargement, we examined the effect of a neutralizing VEGF-antibody (VEGF-ab) on kidney weight and glomerular volume in mice fed a high protein diet for up to seven days.ResultsAt day 2 and day 7 of the experimental period, high protein diet induced a significant increase in the mean glomerular volume. This high protein-induced glomerular hypertrophy was completely prevented by treatment with VEGF-ab. Kidney weight was increased significantly only at day 7, and was not influenced by VEGF-ab treatment. High protein diet and/or VEGF-ab treatment had no effect on body weight, food intake, and liver or heart weight.ConclusionsThe administration of a neutralizing VEGF-ab in mice fed a high protein diet for one week completely abolished the glomerular hypertrophy seen in placebo-treated animals on the same diet, without affecting kidney and body weight. These results demonstrate, to our knowledge for the first time, that high protein-induced glomerular hypertrophy is VEGF-dependent. |
| Databáze: | OpenAIRE |
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