Perirhinal Cortex is Involved in the Resolution of Learned Approach–Avoidance Conflict Associated with Discrete Objects
| Autor: | Edward B. O'Neil, Sonja Chu, Andy C. H. Lee, Sathesan Thavabalasingam, Rutsuko Ito, Matthew Margerison, Yuanfang Zhao |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Cognitive Neuroscience Decision Making Approach-avoidance conflict Hippocampus Stimulus (physiology) Choice Behavior 050105 experimental psychology Temporal lobe Conflict Psychological Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Memory Visual Objects Conflict resolution Perirhinal cortex Avoidance Learning medicine Humans Learning 0501 psychology and cognitive sciences Perirhinal Cortex computer.programming_language Motivation medicine.diagnostic_test Action intention and motor control Functional Neuroimaging 05 social sciences Magnetic Resonance Imaging Temporal Lobe medicine.anatomical_structure Original Article Female Psychology Functional magnetic resonance imaging Neuroscience computer 030217 neurology & neurosurgery |
| Zdroj: | Cereb Cortex Cerebral Cortex, 31, 5, pp. 2701-2719 Cerebral Cortex, 31, 2701-2719 |
| ISSN: | 1460-2199 1047-3211 2701-2719 |
| DOI: | 10.1093/cercor/bhaa384 |
| Popis: | Contains fulltext : 230228.pdf (Publisher’s version ) (Closed access) The rodent ventral and primate anterior hippocampus have been implicated in approach-avoidance (AA) conflict processing. It is unclear, however, whether this structure contributes to AA conflict detection and/or resolution, and if its involvement extends to conditions of AA conflict devoid of spatial/contextual information. To investigate this, neurologically healthy human participants first learned to approach or avoid single novel visual objects with the goal of maximizing earned points. Approaching led to point gain and loss for positive and negative objects, respectively, whereas avoidance had no impact on score. Pairs of these objects, each possessing nonconflicting (positive-positive/negative-negative) or conflicting (positive-negative) valences, were then presented during functional magnetic resonance imaging. Participants either made an AA decision to score points (Decision task), indicated whether the objects had identical or differing valences (Memory task), or followed a visual instruction to approach or avoid (Action task). Converging multivariate and univariate results revealed that within the medial temporal lobe, perirhinal cortex, rather than the anterior hippocampus, was predominantly associated with object-based AA conflict resolution. We suggest the anterior hippocampus may not contribute equally to all learned AA conflict scenarios and that stimulus information type may be a critical and overlooked determinant of the neural mechanisms underlying AA conflict behavior. 19 p. |
| Databáze: | OpenAIRE |
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