Synthesis, evaluation and mechanism exploration of 2-(N-(3-nitrophenyl)-N-phenylsulfonyl)aminoacetohydroxamic acids as novel urease inhibitors

Autor:	Wan-Qing, Song, Mei-Ling, Liu, Liang-Chao, Yuan, Su-Ya, Li, Yi-Ning, Wang, Zhu-Ping, Xiao, Hai-Liang, Zhu
Rok vydání:	2022
Předmět:	Mammals Cell Survival Organic Chemistry Clinical Biochemistry Drug Discovery Animals Pharmaceutical Science Molecular Medicine Urease Molecular Biology Biochemistry
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 78:129043
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2022.129043
Popis:	Thirteen 2-(N-(3-nitrophenyl)-N-phenylsulfonyl)aminoacetohydroxamic acids which were reported for the first time were designed and synthesized as novel urease inhibitors. Most of them showed higher potency than the positive control acetohydroxamic acid, with 2-(N-(3-nitrophenyl)-N-(4-bromophenylsulfonyl)aminoacetohydroxamic acid (d7) being the most active (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7e186d3abfa74fa0f575220f39bd78 https://doi.org/10.1016/j.bmcl.2022.129043 Zobrazit plný text záznamu Full Text from ScienceDirect