High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study

Autor:	Yong Xu, Heng Zhang, Fen Wang, Tao Tan, Chenliang Zhou, Dongwen Wu, Xiao Shi, Xia Tian, Weitian Xu, Wenhu Yu, Jichun Song, Ying Xu, Ji Wang, Jiao Li, Yongxiang Shen, Bitao Chen, Jing Zhou, Xudong Hu, Zhihong Li, Shuzhong Liu, Ting Liu, Zhengwei Cheng, Shihua Zheng, Jie Tang, Mingkai Chen, Hui Long, Shunlin Hu, Huimin Liu, Yong Xiao, Jun Song
Rok vydání:	2021
Předmět:	Adult Liver Cirrhosis Male Microbiology (medical) Gastrointestinal bleeding medicine.medical_specialty Cirrhosis Immunology Infectious and parasitic diseases RC109-216 Biology Logistic regression Severity of Illness Index Microbiology Gastroenterology 03 medical and health sciences Risk Factors Internal medicine Ascites Severity of illness medicine Humans Risk factor Aged Retrospective Studies 030304 developmental biology 0303 health sciences SARS-CoV-2 030306 microbiology Retrospective cohort study Middle Aged Jaundice medicine.disease Infectious Diseases covid-19 risk factor Female Parasitology medicine.symptom decompensated cirrhosis Research Article Research Paper
Zdroj:	Virulence, Vol 12, Iss 1, Pp 1199-1208 (2021) Virulence article-version (VoR) Version of Record
ISSN:	2150-5608 2150-5594
Popis:	Background: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear. Methods: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched non-liver disease patients were enrolled with 1:4 ratio using stratified sampling. Results: There were more comorbidities with higher Chalson Complication Index (p < 0.001), higher proportion of patients having gastrointestinal bleeding, jaundice, ascites, and diarrhea among those patients (p < 0.05) and in decompensated cirrhosis patients. Mortality (p < 0.05) and the proportion of severe ill (p < 0.001) were significantly high among those patients. Patients in severe ill subgroup had higher mortality (p < 0.001), MELD, and CRUB65 score but lower lymphocytes count. Besides, this subgroup had larger proportion of patients with abnormal (PT), activated partial thromboplatin time (APTT), D-Dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL) and Creatinine (Cr) (p < 0.05). Multivariate logistic regression for severity shown that MELD and CRUB65 score reached significance. Higher Child-Pugh and CRUB65 scores were found among non-survival cases and multivariate logistic regression further inferred risk factors for adverse outcome. Receiver Operating Characteristic (ROC) curves also provided remarkable demonstrations for the predictive ability of Child-Pugh and CRUB65 scores. Conclusions: COVID-19 patients with cirrhosis had larger proportion of more severely disease and higher mortality. MELD and CRUB65 score at hospital admission may predict COVID-19 severity while Child-Pugh and CRUB65 score were highly associated with non-survival among those patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7bec9b59a03be876b2462e54d3447b https://doi.org/10.1080/21505594.2021.1909894 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.