MicroRNAs modulate the expression of the SOX18 transcript in lung squamous cell carcinoma
| Autor: | Marzena Podhorska-Okolow, Alina Jankowska-Konsur, Wojciech Witkiewicz, Piotr Dziegiel, Jedrzej Grzegrzolka, Mateusz Olbromski |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Biology 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Cell Line Tumor Internal medicine microRNA SOXF Transcription Factors medicine Humans RNA Messenger Lung cancer Aged Aged 80 and over Oncogene Cancer General Medicine Middle Aged Cell cycle Prognosis medicine.disease Molecular medicine Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Carcinoma Squamous Cell Cancer research Adenocarcinoma Female |
| Zdroj: | Oncology Reports. 36:2884-2892 |
| ISSN: | 1791-2431 1021-335X |
| Popis: | Recent statistics show that lung cancer is the second most common malignant tumor in the world (14% of all cancers in the USA), both in terms of morbidity and mortality. The mortality of this type of tumor shows an increasing trend (28% for men and 26% for women). Lung squamous cell carcinoma (LSCC) is the second‑largest histological subtype of non‑small cell lung cancers (NSCLCs) after adenocarcinoma. SRY‑related HMG‑box 18 (SOX18) protein is an important transcription factor involved in the development of the cardiovascular system and the lymphatic ducts. In addition, it was observed that SOX18 functions in wound healing processes and the development of atherosclerosis. Likewise, an increased level of this protein was found in melanomas and malignant pancreatic, stomach and breast tumors. Furthermore, high expression of SOX18 in gastric cancer stromal cells was found to be associated with a poor patient prognosis. In the present study, we analyzed the expression of the SOX18 protein and the mRNA level in postoperative samples of LSCC and non‑malignant lung tissues (NMLTs), and a disparity in both levels was observed. Because of the fact that microRNAs (miRNAs) play important roles in the initiation and progression of lung cancer, the main aim of this study was to identify the miRNAs that interact with the SOX18 transcript in NSCLC cases. SOX18 mRNA expression level was significantly lower in the LSCC tissues than that noted in the NMLTs (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|