Neuroprotective activity ofStereospermum suaveolensagainst global cerebral ischemia rat model

Autor:	M. H. Shalavadi, A Ramkishan, V. M. Chandrashekhar, Ramesh B. Nidavani, B. S. Biradar
Rok vydání:	2013
Předmět:	Male Antioxidant medicine.medical_treatment Ischemia Administration Oral India Pharmaceutical Science Pharmacology medicine.disease_cause Neuroprotection Brain Ischemia Rats Sprague-Dawley Drug Discovery Animals Medicine Saline Stroke Dose-Response Relationship Drug Stereospermum biology Plant Extracts business.industry Cerebral infarction General Medicine biology.organism_classification medicine.disease Rats Disease Models Animal Neuroprotective Agents Complementary and alternative medicine Reperfusion Injury Anesthesia Bignoniaceae Molecular Medicine Spectrophotometry Ultraviolet Lipid Peroxidation Medicine Traditional business Oxidative stress
Zdroj:	Pharmaceutical Biology. 51:955-960
ISSN:	1744-5116 1388-0209
DOI:	10.3109/13880209.2013.771685
Popis:	Stereospermum suaveolens DC. (Bignoniaceae) is a medicinal tree species native to India. Traditionally, the whole plant is used for various diseases including neuronal disorders.The present study evaluated the neuroprotective activity of Stereospermum suaveolens against global cerebral ischemia in a rat model.Neuroprotective activity was carried out by global cerebral ischemia on Sprague-Dawley rats and divided into five groups of eight rats each; sham and control groups received normal saline (10 ml/kg) and treated groups received methanol extract of Stereospermum suaveolens (MES) orally (125, 250, and 500 mg/kg) for 10 days prior to the experiment. Global cerebral ischemia was induced by bilateral carotid artery (BCA) occlusion for 30 min followed by 4-h reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated by UV spectroscopic method along with cerebral infarction area; histopathological studies were carried out.LD₅₀ of MES was found to be 5000 mg/kg of body weight. The entire test was performed at dose levels 125, 250, and 500 mg/kg of body weight. The results of the study indicate that the Stereospermum suaveolens methanol extract showed neuroprotective activity by a significant decrease in lipid peroxidation (p 0.001) and an increase in superoxide dismutase (p 0.01), catalase (p 0.01), glutathione (p 0.001), and total thiol (p 0.001) levels in extract-treated groups as compared to control group. Measurement of cerebral infarction area and histopathological studies further supported the protective effect of the extract.These findings suggest a potential protective role of Stereospermum suaveolens against global cerebral ischemia/reperfusion-induced brain injury.
Databáze:	OpenAIRE
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