The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model
| Autor: | Elizaveta Ershova, Svetlana Kostyuk, Lev N Porokhovnik, Natalia Veiko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Senescence
Pathology medicine.medical_specialty Aging DNA Copy Number Variations non-coding RNA repetitive sequences Genotoxic Stress Review pendulum model Biology DNA Satellite QH426-470 Tandem repeat Transcription (biology) Stress Physiological Neoplasms copy gain medicine Genetics Humans Copy-number variation Genetics (clinical) 1q12 Mechanism (biology) copy number variation Adaptive response stress response Non-coding RNA genotoxic stress satellite III |
| Zdroj: | Genes, Vol 12, Iss 1524, p 1524 (2021) Genes |
| ISSN: | 2073-4425 |
| Popis: | The pericentric satellite III (SatIII or Sat3) and II tandem repeats recently appeared to be transcribed under stress conditions, and the transcripts were shown to play an essential role in the universal stress response. In this paper, we review the role of human-specific SatIII copy number variation (CNV) in normal stress response, aging and pathology, with a focus on 1q12 loci. We postulate a close link between transcription of SatII/III repeats and their CNV. The accrued body of data suggests a hypothetical universal mechanism, which provides for SatIII copy gain during the stress response, alongside with another, more hypothetical reverse mechanism that might reduce the mean SatIII copy number, likely via the selection of cells with excessively large 1q12 loci. Both mechanisms, working alternatively like swings of the pendulum, may ensure the balance of SatIII copy numbers and optimum stress resistance. This model is verified on the most recent data on SatIII CNV in pathology and therapy, aging, senescence and response to genotoxic stress in vitro. |
| Databáze: | OpenAIRE |
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