Bilateral M1 anodal transcranial direct current stimulation in post traumatic chronic minimally conscious state: a pilot EEG-tDCS study
| Autor: | Sonia Mele, Laila Craighero, Nino Basaglia, Sofia Straudi, Valentina Bonsangue, Felipe Fregni, Andrea Montis, Susanna Lavezzi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Traumatic brain injury medicine.medical_treatment Neuroscience (miscellaneous) Socio-culturale Pilot Projects Electroencephalography Transcranial Direct Current Stimulation tDCS 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Brain Injuries Traumatic medicine Developmental and Educational Psychology Humans In patient Longitudinal Studies coma recovery scale-revised EEG Minimally conscious state traumatic brain injury Neurology (clinical) medicine.diagnostic_test Transcranial direct-current stimulation business.industry Persistent Vegetative State Middle Aged medicine.disease Treatment Outcome Female Open label 0305 other medical science business 030217 neurology & neurosurgery |
| Popis: | We tested the preliminary effects of bilateral anodal transcranial direct current stimulation (tDCS) in patients with disorders of consciousness.Open label pilot study.Ten chronic (greater than 12 months) patients in a minimally conscious state (MCS) following severe traumatic brain injury.The patients received 10 sessions of bilateral M1 anodal tDCS. Behavioural changes were assessed with the Coma Recovery Scale-Revised (CRS-R) before stimulation (T-1, T0), after five sessions (T1), at the end of the stimulation (T2), after two weeks (T3) and after three months (T4). Moreover, an EEG assessment was conducted.Eight out of 10 patients showed new clinical signs of consciousness; specifically, a 2-point CRS-R improvement was detected in the last follow-up (p = 0.004). EEG upper α bandwidth was greater in the parietal site at T1 (p 0.034). In addition, we found a significant correlation between behavioral and EEG indices at T1 (r = 0.89; p = 0.001).This preliminary study presents several limitations (small sample size and no control group). However, it provides important initial data that can be used to design randomized clinical trials testing this novel approach in MCS and to further explore EEG as a neural marker for the effects of tDCS. |
| Databáze: | OpenAIRE |
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