Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D-galactose induced aging in rats
| Autor: | Yung Ming Chang, Yueh Min Lin, Vijaya Padma Viswanadha, Chin Chuan Tsai, Hsin Nung Chang, Hung-Jen Lin, Cecilia Hsuan Day, Shanmugam Tamilselvi, Wei Wen Kuo, Chih Yang Huang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Aging Cardiac fibrosis Health Toxicology and Mutagenesis 010501 environmental sciences Management Monitoring Policy and Law Pharmacology Toxicology Protective Agents 01 natural sciences Rats Sprague-Dawley Transforming Growth Factor beta1 03 medical and health sciences chemistry.chemical_compound Random Allocation 0302 clinical medicine Downregulation and upregulation Fibrosis Medicine Animals 0105 earth and related environmental sciences business.industry Myocardium Galactose Heart General Medicine medicine.disease Pathophysiology Rats Blot chemistry 030220 oncology & carcinogenesis Fruit Alpinia Matrix Metalloproteinase 2 Collagen business Wound healing Immunostaining Drugs Chinese Herbal |
| Zdroj: | Environmental toxicology. 34(2) |
| ISSN: | 1522-7278 |
| Popis: | Cardiac fibrosis is a common pathophysiological process observed during chronic and stress-induced acceleration of cardiac aging. Fibrosis is a necessary process during wound healing and tissue repair. However, its deposition in organs would proceed to scarring and organ damage. Here Alpinate Oxyphyllae Fructus (AOF), a Chinese medicine extract was used to protect aging heart from collagen accumulation. About 8 weeks old, male SD rats were randomly divided into (i) Control, (ii) D-galactose induced aging (IA), (iii) IA + AOF 50 (AOF low, AL), (iv) IA + AOF 100 (AOF medium, AM), (v) IA + AOF 150 (AOF high, AH) mg/kg/day, AOF was administered orally. After 8 weeks rats were sacrificed and hearts were collected. Results showed collagen deposition and up-regulation of matrix metalloproteinases-MMP-2 and -9 in D-galactose-induced aging rats. Furthermore, western blotting and immunostaining were also confirmed the upregulation of TGF-β1 mediated fibrosis in aging induced rats. However, collagen deposition and fibrosis were significantly decreased by AOF treatments (AM and AH). AOF treatments salvaged the cardiac fibrosis. Hence, AOF might be a potential therapeutic agent in the prevention of cardiac fibrosis associated with aging. The protective effects of AOF might have promising results in anti-aging treatments. |
| Databáze: | OpenAIRE |
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