Galactomannan from the seeds of Caesalpinia pulcherrima prevents indomethacin-induced gastrointestinal damage via neutrophil migration
| Autor: | Judith P.A. Feitosa, Fabrícia da Cunha Jácome Marques, Marcellus H.L.P. Souza, Patrícia da Silva Pantoja, Victor Emanuel Araujo Matos, Samara R.B. Damasceno, Álvaro Xavier Franco, Priscilla F. C. Justino, Pedro Marcos Gomes Soares, Renan O. Silva, Rondinelle Ribeiro Castro, Rômulo Couto Alves |
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| Rok vydání: | 2019 |
| Předmět: |
Thiobarbituric acid
Neutrophils Indomethacin 02 engineering and technology Pharmacology Biochemistry Mannans 03 medical and health sciences Galactomannan chemistry.chemical_compound Mice Structural Biology TBARS medicine Animals Molecular Biology 030304 developmental biology 0303 health sciences Caesalpinia Acute Gastritis biology Stomach Mucin Galactose General Medicine 021001 nanoscience & nanotechnology Caesalpinia pulcherrima biology.organism_classification medicine.anatomical_structure chemistry Neutrophil Infiltration Gastritis Acute Disease Seeds Female medicine.symptom 0210 nano-technology |
| Zdroj: | International journal of biological macromolecules. 141 |
| ISSN: | 1879-0003 |
| Popis: | Galactomannans are neutral polysaccharides isolated from the endosperm of some Leguminosae seeds. They consist of a (1 → 4) linked β-mannopyranosyl backbone partially substituted at O-6 with α- d -galactopyranosyl side groups. C. pulcherrima have anti-inflammatory and muco-adhesive proprieties. Acute gastritis is an inflammatory disease triggered by use of non-steroidal anti-inflammatory drugs. We investigated the gastroprotective effect of galactomannan obtained from the seeds of Caesalpinia pulcherrima L. (GM-CP) in acute gastritis model induced by indomethacin. Gastritis was induced with indomethacin (30 mg/kg, P.·O.) in female Swiss mice. Animal groups (n = 7) were pretreated with saline-dissolved GM-CP (3 mg/kg, 10 mg/kg, 30 mg/kg, P.O.) or vehicle 1 h before gastritis induction. Mice were euthanized seven hours after the induction. The stomach and blood samples were collected for analysis. At 10 mg/kg, GP-CP reduced the extension of macroscopic lesion and the loss of superficial cells by alleviating inflammatory symptoms (neutrophil infiltration, migration and adhesion of mesenteric leukocytes, production of TNF-α and thiobarbituric acid reactive species (TBARS) and helping to maintain mucin labeling of the tissue. Thus, the findings of the study suggest that GM-CP exhibits gastroprotective effects. |
| Databáze: | OpenAIRE |
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