| Popis: |
— The effectiveness of microwave-assisted preparation of N-alkylisatin-b-thiocarbohydrazones, where alkyl group is methyl and ethyl, was evaluated. The corresponding N-alkylisatin-b-thiocarbohydrazones were predominantly obtained by TCH and N-alkyl substituted isatin in molar ratio 3:1. Reactions of carbonyl-amine condensation were performed in water acidified to pH 1.5 as a solvent system. Reaction mixtures were exposed to microwave irradiation under 300W and pressure 200 psi, for a specified incubation period of 5-15 min. The yield of products obtained by microwave assisted reaction was similar to that had been obtained using conventional reflux method (about 70% to 80%), with reduction of time. The structures of synthesized N-alkylisatins and corresponding N-alkylisatin-b-thiocarbohydrazones were established on the basis of recorded spectral data from IR, GC-MS, 1H NMR and 13C NMR. |
