Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma
| Autor: | Radoslav Davidovic, Branko Dozic, Sofija Glumac, Ivana Baralic, Jelena Sopta, Maja Medojevic Pavlovic, Ana Todorović, Ivan Pavlović, Sasa Hinic, Sanja Radojevic Skodric, Snezana Pejic, Dunja Drakulić |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Soft Tissue Neoplasms Cyclin-Dependent Kinase Inhibitors Pathology and Forensic Medicine Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Rhabdomyosarcoma medicine Humans Epigenetics Child Cyclin-Dependent Kinase Inhibitor p57 Cyclin-Dependent Kinase Inhibitor p16 Aged 030304 developmental biology 0303 health sciences business.industry Soft tissue sarcoma Infant Cancer P16 Cell Biology Middle Aged medicine.disease Immunohistochemistry P57 3. Good health Survival Rate Child Preschool 030220 oncology & carcinogenesis Cancer research Female Lymph business |
| Zdroj: | Pathology-Research and Practice |
| Popis: | Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults ( 50 yrs. (HR 2.447), tumors > 5 cm (HR 21.31), involvement of regional lymph nodes (HR 3.96), the presence of metastases (HR 2.53), and low p57 expression (HR 2.11) as predictors of lower OS. Tumor size, regional lymph nodes involvement, and metastases were the independent predictors after multivariate analysis, while p57 did not predict OS in an independent way. In summary, although p57 was not confirmed to be an independent predictor of OS, our results indicate that its low expression may be the marker of aggressive phenotype and poor prognosis in adult RMS patients. Also, our findings suggest that epigenetic inactivation of p16 is not important in the pathogenesis of rhabdomyosarcoma. |
| Databáze: | OpenAIRE |
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