Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonide
| Autor: | Wolfgang Timmer, Anton Drollmann, Georg P. Engel, Wilhelm Wurst, Zschiesche M, Anita Weinbrenner, Volker W. Steinijans, Werner Siegmund, T.D. Bethke, Hans Joachim Kaatz, Dagny Hüneke |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Evening Hydrocortisone Endocrinology Diabetes and Metabolism Clinical Biochemistry Ciclesonide Placebo Biochemistry Drug Administration Schedule chemistry.chemical_compound Endocrinology Double-Blind Method Pregnenediones Internal medicine Administration Inhalation medicine Humans Circadian rhythm Anti-Asthmatic Agents Morning Inhalation Dose-Response Relationship Drug business.industry Biochemistry (medical) Circadian Rhythm chemistry business Glucocorticoid medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 87(5) |
| ISSN: | 0021-972X |
| Popis: | The new inhalative glucocorticoid ciclesonide which is activated in lung to a more potent metabolite was hypothesized to have low risk for systemic and local side-effects in man. Therefore, a placebo-controlled, randomized, double-blind, four-period, change-over equivalence study in 12 healthy male volunteers (age 21-28 yr, body weight 62-90 kg) was conducted to assess the influence of three dosage regimens (800 microg in the morning, 800 microg in the evening, 400 microg twice daily for 7 d, metered inhalers) on the circadian time serum cortisol rhythm.Serum cortisol showed the typical circadian rhythm. The geometric mean of the 24-h mesor (AUC((0-24 h))/24 h) was 7.22 microg/dl for placebo, 6.75 microg/dl for the 800 microg ciclesonide morning dose, 7.08 microg/dl for the 800 microg evening dose, and 6.75 microg/dl for 400 microg ciclesonide inhaled twice daily. Because there was also no influence on cortisol amplitude and acrophase (time of maximum), the profiles after ciclesonide were equivalent to the placebo control. The small differences were considered not to be of clinical significance. In conclusion, inhaled ciclesonide in daily doses of 800 microg for 7 d is without clinically relevant effects on the hypothalamic-pituitary-adrenal axis independent of the time of administration. |
| Databáze: | OpenAIRE |
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