N-terminal truncations in sex steroid receptors and rapid steroid actions
| Autor: | Rebecca L. Cunningham, Phong Duong, Derek A. Schreihofer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Receptors Steroid medicine.medical_specialty Clinical Biochemistry Estrogen receptor Immune receptor Biology Ligands Biochemistry Article 03 medical and health sciences Endocrinology Internal medicine Caveolin medicine Animals Humans Protein Isoforms Receptor Molecular Biology Transcription factor Sequence Deletion PELP-1 Pharmacology Organic Chemistry Sex hormone receptor Cell biology Androgen receptor 030104 developmental biology Steroids |
| Zdroj: | Steroids. 133:15-20 |
| ISSN: | 0039-128X |
| Popis: | Sex steroid receptors act as ligand activated nuclear transcription factors throughout the body, including the brain. However, post-translational modification of these receptors can direct them to extranuclear sites, including the plasma membrane, where they are able to initiate rapid signaling. Because of the conserved domain structure of these receptors, alternative exon splicing can result in proteins with altered nuclear and extranuclear actions. Although much attention has focused on internal and C-terminal splice variants, both estrogen and androgen receptors undergo N-terminal truncations, as well. These truncated proteins not only influence the transcriptional activity of the full-length receptors, but also associate with caveolin and initiate signaling at the plasma membrane. Such actions may have important physiological consequences in neuronal, endothelial, and cancer signaling and cell survival. |
| Databáze: | OpenAIRE |
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