Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina
| Autor: | Wilfried Karmaus, Andrew B. Lawson, Lawrence C. Mohr, Bo Cai, James J. Gibson, Kathleen A. Clark, Pallavi Balte, John E. Vena, Erik R. Svendsen, Dennis R. Ownby |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine South carolina Spirometry Chemical Hazard Release South Carolina History 21st Century Disasters 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine medicine Humans Longitudinal Studies 030212 general & internal medicine Employee health Lung Railroads Lung function Original Research Chlorine gas Inhalation Exposure medicine.diagnostic_test business.industry Technician Regression analysis Middle Aged respiratory tract diseases 030228 respiratory system Textile Industry Regression Analysis Female Chlorine business Demography |
| Zdroj: | Annals of the American Thoracic Society. 13:356-363 |
| ISSN: | 2325-6621 2329-6933 |
| DOI: | 10.1513/annalsats.201508-525oc |
| Popis: | On January 6, 2005 a train derailment led to an estimated 54,915-kg release of chlorine at a local textile mill in Graniteville, South Carolina.We used the employee health spirometry records of the textile to identify enduring effects of chlorine gas exposure resulting from the incident on the lung function of workers employed at the textile mill.Spirometry records from 1,807 mill workers (7,332 observations) were used from 4 years before and 18 months after the disaster. Longitudinal analysis using marginal regression models produced annual population mean estimates for FEV1, FVC, and FEV1/FVC ratio. Covariate adjustment was made for sex, age, smoking, height, season tested, technician, obesity, season × year interactions, and smoker × year interactions. The increased prevalence of mill workers having accelerated FEV1 decline was also evaluated after the chlorine spill.In the year of the accident, we observed a significant reduction in mean FEV1 (-4.2% predicted; P = 0.019) when compared with the year before the incident. In the second year, partial recovery in the mean FVC % predicted level was seen, but the cohort's average FEV1/FVC ratio continued to decrease over time. Severe annual FEV1 decline was most prevalent in the year of the accident, and independent of mill worker smoking status.The Graniteville mill worker cohort revealed significant reductions in lung function immediately after the chlorine incident. Improvement was seen in the second year; but the proportion of mill workers experiencing accelerated FEV1 annual decline significantly increased in the 18 months after the chlorine incident. |
| Databáze: | OpenAIRE |
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