Efficacy of Sublingual Immunotherapy with Dermatophagoides farinae Extract in Monosensitized and Polysensitized Patients with Allergic Rhinitis: Clinical Observation and Analysis
| Autor: | Ying He, Chen-Xia Xu, Qiu-Rong Wu, Bi-Zhou Li, Zehong Zou, Ailin Tao, Jin-Lu Sun, He Lai, Miao-Lian Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Article Subject Rhinitis allergic Treatment outcome Dose-Response Relationship Immunologic Dermatophagoides farinae extract lcsh:Medicine Cross Reactions General Biochemistry Genetics and Molecular Biology immune system diseases Mite Animals Humans Medicine Sublingual immunotherapy Antigens Dermatophagoides Phylogeny Skin Tests Curative effect Sublingual Immunotherapy Dermatophagoides farinae General Immunology and Microbiology biology business.industry Significant difference lcsh:R General Medicine biology.organism_classification Rhinitis Allergic Slit Dermatology respiratory tract diseases Treatment Outcome Immunology Clinical Study Immunization business |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Aim. To investigate differences in the efficacy of sublingual immunotherapy withDermatophagoides farinaedrops in monosensitized and polysensitized allergic rhinitis patients.Methods. The patients enrolled in the study were treated for more than one year by sublingual immunotherapy (SLIT) usingDermatophagoides farinaedrops and were divided into a monosensitized group (n=20) and a polysensitized group (n=30). Total nasal symptom scores of patients before and after SLIT were analyzed to evaluate the curative effect. The phylogenetic tree of dust mite allergens as well as other allergens that were tested by skin prick test was constructed to help the analysis.Results. There was no significant difference in the efficacy of SLIT between dust mite monosensitized and polysensitized patients.Conclusions. Both dust mite monosensitized and polysensitized patients could be cured by SLIT usingDermatophagoides farinaedrops. This study provides a reference for the selection of allergens to be used in immunotherapy for polysensitized AR patients. |
| Databáze: | OpenAIRE |
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