Analgesic and antiinflammatory ectivity of Cyclamen repandum S. et S
| Autor: | Gabbriella Innocenti, Stefano Dall'Acqua, Stefano Costa, Rinaldo Cervellati, Ester Speroni, Maria Clelia Guerra, C. Panizzolo, Aneli Utan |
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| Přispěvatelé: | E. Speroni, R. Cervellati, S. Costa, S. Dall'Acqua, M.C. Guerra, C. Panizzolo, A. Utan, G. Innocenti |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Saponin Anti-Inflammatory Agents Pain Pharmacognosy Carrageenan Rats Sprague-Dawley Mice Bioassay Animals Edema Medicinal plants Cyclamen Acetic Acid Pain Measurement Pharmacology chemistry.chemical_classification Analgesics biology Traditional medicine Plant Extracts biology.organism_classification Rats Primulaceae Phytochemical chemistry Cyclamen repandum Phytotherapy |
| Popis: | According to folk medicine some species belonging to the genus Cyclamen were used for their biological activities. Early investigation of the different species of the genus resulted in the isolation of triterpenic saponins. No phytochemical and biological data are available on C. repandum. As part of a series of phytochemical investigations for bioactive compounds from medicinal plants, Cyclamen repandum S. et S. was investigated. The present study sought to find the antiinflammatory and antinociceptive activities of C. repandum tubers in rats and mice. A preliminary screening was conducted with three different extracts in the tests used, particularly the paw edema and the writhing tests. Subsequently some saponins isolated from the ME extract, the more effective one, have been identified. This paper also describes the results of fractionation and bioassay guided chemical studies. Chemical investigation of the active extract afforded the isolation and characterization of six triterpenic saponins. The possible antiinflammatory and analgesic properties were investigated as the saponin content of the fractions allows to speculate on such aspect. |
| Databáze: | OpenAIRE |
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