A rare rarity: neuroendocrine tumor of the esophagus
| Autor: | Giannetta, Elisa, Guarnotta, Valentina, Rota, Francesca, de Cicco, Federica, Grillo, Federica, Colao, Annamaria, Faggiano, Antongiulio, Albertelli, M., Bianchi, A., Circelli, L., Dicitore, A., Di Dato, C., Di Molfetta, S., Fanciulli, G., Ferrau, F., Gallo, M., Grossrubatscher, E., Guadagno, E., Lo Calzo, F., Kara, E., Malandrino, P., Messina, E., Modica, R., Muscogiuri, G., Pizza, G., Razzore, P., Rubino, M., Ruggeri, R. M., Sciammarella, C., Vitale, G., Zatelli, M. C. |
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| Přispěvatelé: | Giannetta, Elisa, Guarnotta, Valentina, Rota, Francesca, de Cicco, Federica, Grillo, Federica, Colao, Annamaria, Faggiano, Antongiulio, Albertelli, M., Bianchi, A., Circelli, L., Dicitore, A., Di Dato, C., Di Molfetta, S., Fanciulli, G., Ferrau, F., Gallo, M., Grossrubatscher, E., Guadagno, E., Lo Calzo, F., Kara, E., Malandrino, P., Messina, E., Modica, R., Muscogiuri, G., Pizza, G., Razzore, P., Rubino, M., Ruggeri, R. M., Sciammarella, C., Vitale, G., Zatelli, M. C. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Carcinoid tumors esophageal neoplasms Neuroendocrine tumors Small-cell carcinoma Gastroenterology 03 medical and health sciences 0302 clinical medicine gastroenteropancreatic NET Internal medicine Epidemiology medicine risk factors esophageal NEC large cell esophageal NEN MANEC small cell carcinoma delayed diagnosis humans neuroendocrine tumors prognosis rare diseases Esophagus Stage (cooking) business.industry Large cell Hematology medicine.disease Dysphagia 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis medicine.symptom business |
| Popis: | Esophageal Neuroendocrine tumors (NETs) are rare, aggressive and lacking specific symptoms. This causes a diagnostic delay, worsening the prognosis. Numerous cases are reported in literature, without a consensus on the management. Our aim was to clarify epidemiology, clinical presentation, diagnostic, therapeutic management of esophageal NETs. Extensive literature search identified a total of 226 articles. One hundred twenty-five articles (n = 1676) met the inclusion criteria, showing that: the incidence of esophageal NET varies geographically; men (60–70 years) are more affected; smoking and alcohol abuse are the major risk factors; dysphagia, weight loss, appetite loss are the most common clinical features. The histotypes include high-grade small and large cell esophageal carcinomas and low-grade carcinoid tumors. Mixed neuroendocrine/non-neuroendocrine neoplasms are the most common. Often the diagnosis occurs randomly on endoscopic examination. Circulating markers, functional combined with conventional imaging contributes to the diagnosis and management. Treatment depends on type, grade and stage of the tumor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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