Is there a causal relationship between acute stage sensorimotor cortex activity and the development of chronic low back pain? a protocol and statistical analysis plan
| Autor: | Valentina Buscemi, Aidan G Cashin, Wei-Ju Chang, Matthew B Liston, James H. McAuley, Siobhan M Schabrun, Luke C Jenkins, Chelsea N Cunningham |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
aetiology medicine.medical_treatment Rehabilitation Medicine 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation motor cortex sensory cortex transcranial magnetic stimulation Protocol medicine Humans 030212 general & internal medicine Sensory cortex causal inference Causal model Models Statistical business.industry Chronic pain General Medicine medicine.disease Acute Pain Low back pain confounding 3. Good health Transcranial magnetic stimulation medicine.anatomical_structure Research Design Roland Morris Disability Questionnaire Somatosensory evoked potential Causal inference directed acyclic graph Sensorimotor Cortex Chronic Pain medicine.symptom business Low Back Pain electroencephalography 030217 neurology & neurosurgery |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 1261-9000 |
| Popis: | IntroductionWhy some people develop chronic pain following an acute episode of low back pain is unknown. Recent cross-sectional studies have suggested a relationship between aberrant sensorimotor cortex activity and pain persistence. The UPWaRD (Understanding persistent Pain Where it ResiDes) cohort study is the first prospective, longitudinal investigation of sensorimotor cortex activity in low back pain. This paper describes the development of a causal model and statistical analysis plan for investigating the causal effect of sensorimotor cortex activity on the development of chronic low back pain.Methods and analysisSensorimotor cortex activity was assessed within 6 weeks of low back pain onset using somatosensory evoked potentials and transcranial magnetic stimulation mapping techniques. Chronic low back pain is defined as ongoing pain (Numerical Rating score ≥1) or disability (Roland Morris Disability Questionnaire score ≥3) at 6 months follow-up. Variables that could confound the relationship between sensorimotor cortex activity and chronic low back pain were identified using a directed acyclic graph and content expertise was used to specify known causal paths. The statistical model was developed ‘a priori’ to control for confounding variables identified in the directed acyclic graph, allowing an unbiased estimate of the causal effect of sensorimotor activity in acute low back pain on the development of chronic pain. The statistical analysis plan was finalised prior to follow-up of all participants and initiation of analysis.Ethics and disseminationEthical approval has been obtained from Western Sydney University Human Research Ethics Committee (H10465) and from Neuroscience Research Australia (SSA: 16/002). Dissemination will occur through presentations at national and international conferences and publications in international peer-reviewed journals.Trial registration numberACTRN12619000002189 (retrospectively registered) |
| Databáze: | OpenAIRE |
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