Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics - a Minireview

Autor:	Jae Yoon Jeon, Vivaswath S. Ayyar, Amitava Mitra
Rok vydání:	2022
Předmět:	Pharmacology Organic Chemistry Liposomes Pharmaceutical Science Molecular Medicine Nanoparticles Pharmacology (medical) RNA Small Interfering Models Biological Biotechnology
Zdroj:	Pharmaceutical research. 39(8)
ISSN:	1573-904X
Popis:	The approval of four small interfering RNA (siRNA) products in the past few years has demonstrated unequivocally the therapeutic potential of this novel modality. Three such products (givosiran, lumasiran and inclisiran) are liver-targeted, using tris N-acetylgalactosamine (GalNAc)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c712cb90eae2b4ef0afd50b247c1d78 https://pubmed.ncbi.nlm.nih.gov/35819583 Zobrazit plný text záznamu Full text from SpringerLink