The localization of oxytocin receptors in the islets of Langerhans in the rat pancreas
| Autor: | Sadahiko Masuko, Motoaki Suzuki, Ming-Zi Li, Yuko Honda, Yuzo Murata |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Physiology medicine.medical_treatment Clinical Biochemistry Biochemistry Glucagon Rats Sprague-Dawley Islets of Langerhans Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Animals Rat Pancreas Messenger RNA geography geography.geographical_feature_category Reverse Transcriptase Polymerase Chain Reaction Chemistry Insulin Islet Immunohistochemistry Oxytocin receptor Rats Oxytocin Receptors Oxytocin Female medicine.drug |
| Zdroj: | Regulatory Peptides. 183:42-45 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2013.03.019 |
| Popis: | In this study, oxytocin receptors (OTRs) in the islets of Langerhans were detected using real-time RT-PCR and immunohistochemical technique. Indeed, OTR mRNA was expressed in the rat pancreas. Double immunohistochemical staining for OTR and either glucagon or insulin demonstrated their co-localization in A-cells or B-cells, respectively. OTR-immunoreactivity in A-cells was stronger than that of B-cells. All A-cells and 94.8% of B-cells were OTR-immunoreactive. We reveal the statistically significant relations of OTR with A-cells and B-cells in the islets of Langerhans. This is the first demonstration of the OTR localization in the islets of Langerhans immunohistochemically. It suggests that oxytocin (OT) is involved in the release of insulin and glucagon. |
| Databáze: | OpenAIRE |
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