Functional assessment of the ex vivo vocal folds through biomechanical testing: A review
| Autor: | Scott Roof, Seema Jeswani, Ryan C. Branski, Paulo G. Coelho, Mark A. Fritz, Milan R. Amin, Michael C. Sobieraj, Gregory R. Dion |
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| Rok vydání: | 2016 |
| Předmět: |
Micrometer scale
Materials science Bioengineering Nanotechnology Vocal Cords Biomechanical testing Models Biological 01 natural sciences Article Biomechanical Phenomena Biomaterials 03 medical and health sciences 0302 clinical medicine 0103 physical sciences otorhinolaryngologic diseases medicine Humans Phonation 030223 otorhinolaryngology 010301 acoustics Rheometry Biomechanics medicine.anatomical_structure Mechanics of Materials Vocal folds Ex vivo Biomedical engineering |
| Zdroj: | Materials Science and Engineering: C. 64:444-453 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.04.018 |
| Popis: | The human vocal folds are complex structures made up of distinct layers that vary in cellular and extracellular composition. The mechanical properties of vocal fold tissue are fundamental to the study of both the acoustics and biomechanics of voice production. To date, quantitative methods have been applied to characterize the vocal fold tissue in both normal and pathologic conditions. This review describes, summarizes, and discusses the most commonly employed methods for vocal fold biomechanical testing. Force-elongation, torsional parallel plate rheometry, simple-shear parallel plate rheometry, linear skin rheometry, and indentation are the most frequently employed biomechanical tests for vocal fold tissues and each provide material properties data that can be used to compare native tissue verses diseased for treated tissue. Force-elongation testing is clinically useful, as it allows for functional unit testing, while rheometry provides physiologically relevant shear data, and nanoindentation permits micrometer scale testing across different areas of the vocal fold as well as whole organ testing. Thoughtful selection of the testing technique during experimental design to evaluate a hypothesis is important to optimizing biomechanical testing of vocal fold tissues. |
| Databáze: | OpenAIRE |
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