Inhibition of the in vitro generation of class II-restricted, HSV-1-specific, CD4+ CTL by HIV-1
| Autor: | Ridgeway Mr, Mawle Ac, Thieme Ml, Schmid Ds, McDougal Js |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Herpesvirus 4
Human Cell Survival Lymphocyte Immunology chemical and pharmacologic phenomena Biology medicine.disease_cause Major histocompatibility complex Herpesviridae Virus Antigen Virology medicine Tumor Cells Cultured Cytotoxic T cell Animals Humans Simplexvirus Histocompatibility Antigens Class II HLA-DR Antigens Cell Transformation Viral CTL Infectious Diseases medicine.anatomical_structure biology.protein HIV-1 CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | AIDS research and human retroviruses. 6(2) |
| ISSN: | 0889-2229 |
| Popis: | Previously, we demonstrated that cultures of human peripheral blood lymphocytes (PBL) stimulated with herpes simplex virus type 1 (HSV-1) generate antigen-specific, major histocompatibility complex (MHC) restricted cytotoxic T lymphocytes (CTL) that tend to be CD4+ and restricted to HLA-DR antigens. In this study, we present evidence that when HSV-1 stimulated human peripheral blood lymphocytes (PBL) are cocultured with human immunodeficiency virus type 1 (HIV-1), the generation of CD4+, DR-restricted CTL during the 5-day culture period is inhibited. In contrast, HIV-1 had no effect on either natural killer (NK) activity, or on the unrestricted NK-like killers which are often detected in HSV-1-stimulated cultures after the depletion of CD16+ cells. HIV-1 also failed to inhibit the generation of CTL against Epstein-Barr virus (EBV), a response that principally involves CD8+, CD4-, class I-restricted killers. |
| Databáze: | OpenAIRE |
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