Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior
| Autor: | Kathryn D. Fischer, Paul A. Rosenberg, Lori A. Knackstedt |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Substance-Related Disorders media_common.quotation_subject Dopamine Glutamic Acid Nucleus accumbens Nucleus Accumbens Article 03 medical and health sciences Cellular and Molecular Neuroscience Health problems 0302 clinical medicine Glutamate homeostasis medicine Animals Homeostasis Humans Amphetamine media_common business.industry Addiction Dopaminergic Neurons Ventral Tegmental Area Cell Biology Ventral tegmental area Behavior Addictive 030104 developmental biology medicine.anatomical_structure Excitatory postsynaptic potential Central Nervous System Stimulants business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurochem Int |
| ISSN: | 1872-9754 |
| Popis: | Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide health problems. To date, there are no FDA-approved medications for the treatment of these disorders. Elucidation of the biochemical underpinnings contributing to psychostimulant addiction is critical for the development of effective therapies. Excitatory signaling and glutamate homeostasis are well known pathophysiological substrates underlying addiction-related behaviors spanning multiple types of psychostimulants. To alleviate relapse behavior to psychostimulants, considerable interest has focused on GLT-1, the major glutamate transporter in the brain. While many brain regions are implicated in addiction behavior, this review focuses on two regions well known for their role in mediating the effects of cocaine and amphetamines, namely the nucleus accumbens (NAc) and the ventral tegmental area (VTA). In addition, because many investigators have utilized Cre-driver lines to selectively control gene expression in defined cell populations relevant for psychostimulant addiction, we discuss potential off-target effects of Cre-recombinase that should be considered in the design and interpretation of such experiments. |
| Databáze: | OpenAIRE |
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