Prevalence of LDL atherogenic phenotype in patients with systemic lupus erythematosus
| Autor: | Samuel Olusi, Sunila George |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Apolipoprotein B Endocrinology Diabetes and Metabolism chemistry.chemical_compound systemic lupus erythematosus immune system diseases Prevalence Lupus Erythematosus Systemic Pharmacology (medical) skin and connective tissue diseases Original Research education.field_of_study biology Hematology General Medicine Middle Aged particle size Phenotype Kuwait Low-density lipoprotein Regression Analysis lipids (amino acids peptides and proteins) Electrophoresis Polyacrylamide Gel Female Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty Population Internal medicine medicine Humans education Triglycerides Apolipoproteins B Triglyceride Cholesterol business.industry Cholesterol HDL Public Health Environmental and Occupational Health Cholesterol LDL medicine.disease Atherosclerosis Vascular Health and Risk Management Endocrinology chemistry low-density lipoprotein Case-Control Studies biology.protein business Dyslipidemia Biomarkers Anti-SSA/Ro autoantibodies Lipoprotein |
| Zdroj: | Vascular Health and Risk Management |
| ISSN: | 1178-2048 |
| Popis: | Samuel O Olusi, Sunila GeorgeDepartment of Pathology, Faculty of Medicine, Kuwait University, KuwaitBackground: Patients with systemic lupus erythematosus (SLE) are 5–8 times more likely to develop coronary heart disease than the general population. The aim of this study was to find out the prevalence of the small dense low-density lipoprotein (LDL) cholesterol particle in patients with SLE.Methods: We recruited 50 consecutive patients with SLE who had no evidence of hypertension or renal failure. Fifty age- and gender-matched healthy controls were also recruited. We measured serum lipid levels and LDL particle diameters by gradient gel electrophoresis in both patients and controls.Results: Patients with SLE had significant dyslipidemia, characterized by elevated plasma triglycerides, LDL cholesterol, Apoprotein B, triglyceride:high-density (HDL) lipoprotein cholesterol ratio, and decreased plasma concentrations of HDL cholesterol. The LDL particle size in SLE (24.8 ± 1.23 nm) was significantly (P < 0.01) smaller than that in controls (26.1 ± 1.31 nm). The prevalence of the LDL phenotype B (the atherogenic phenotype) was 52% in SLE but only 20% in healthy controls.Conclusion: We conclude that the high prevalence of small dense LDL in SLE may contribute to the high incidence of coronary heart disease seen in this disorder.Keywords: low-density lipoprotein, particle size, atherosclerosis, systemic lupus erythematosus |
| Databáze: | OpenAIRE |
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