Immediate and long-term effects of bilateral electroconvulsive therapy on cognitive functioning in patients with a depressive disorder

Autor: Jasper O. Nuninga, Steven C. Bakker, Metten Somers, Marco P. Boks, Marieke J.H. Begemann, Sophie M. Heringa, Wendy Nieuwdorp, René C.W. Mandl, Thomas F.I. Claessens, Iris E. C. Sommer
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Movement Disorder (MD)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Audiology
Neuropsychological Tests
behavioral disciplines and activities
Time
03 medical and health sciences
0302 clinical medicine
Electroconvulsive therapy
Cognition
Visual memory
mental disorders
medicine
Verbal fluency test
Humans
Effects of sleep deprivation on cognitive performance
Cognitive skill
Longitudinal Studies
Electroconvulsive Therapy
PERSPECTIVE
METAANALYSIS
Depressive Disorder
Major
business.industry
MEMORY
AMNESIA
ECT
MAJOR DEPRESSION
Middle Aged
ELECTRODE PLACEMENT
IMPAIRMENT
EFFICACY
DYSFUNCTION
030227 psychiatry
Cognitive test
Clinical Psychology
Psychiatry and Mental health
Treatment Outcome
Case-Control Studies
Female
Verbal memory
business
Cognition Disorders
030217 neurology & neurosurgery
Zdroj: Journal of Affective Disorders, 238, 659-665. ELSEVIER SCIENCE BV
Journal of Affective Disorders, 238, 659. Elsevier
ISSN: 1573-2517
0165-0327
Popis: Background: Electroconvulsive therapy (ECT) is the most effective treatment for patients suffering from major depression. However, its use is limited due to concerns about negative effects on cognition. Unilateral ECT is associated with transient cognitive side-effects, while case-controlled studies investigating the effect of bilateral ECT on cognition remain scarce. We investigate the effects of bilateral ECT on cognition in depression in a longitudinal case-controlled study. We hypothesize that adverse cognitive effects of bilateral ECT are transient rather than long-term.Methods: A total of 48 depressed patients and 19 controls were included in the study and assessed with a battery of cognitive tests, including tests of: working memory, verbal fluency, visuospatial abilities, verbal/visual memory and learning, processing speed, inhibition, attention and task-switching, and premorbid IQ. Patients underwent three cognitive assessments: at baseline (n=43), after ten ECT sessions (post-treatment; n=39) and six months after the tenth ECT session (follow-up; n=25). Healthy controls underwent the same cognitive assessment at baseline and after five-weeks.Results: Within the patient group, transient adverse cognitive side-effects were observed for verbal memory and learning, and verbal fluency. None of the cognitive domains tested in this study showed persisting impairments.Limitations: A relatively high attrition rate is observed and autobiographical memory was not assessed.Conclusion: This study shows that bilateral ECT has negative cognitive effects on short-term. These effects could be explained by a decrease in cognitive performance, a lack of learning effects or a combination. However, the decrease in cognitive functioning appears to recover after six months.
Databáze: OpenAIRE
Externí odkaz: