Problems with NASH? HAIR is some help. Dixon JB, Bhathal PS, O'Brien PE, Nonalcoholic Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Liver Fibrosis in the Severely Obese, Gastroenterology 2001;121:91-100
| Autor: | Luis A. Balart, Harvey Phillips |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Scoring system Cirrhosis Population Gastroenterology Liver disease Insulin resistance Weight loss Internal medicine Nonalcoholic fatty liver disease medicine education education.field_of_study Hepatology medicine.diagnostic_test business.industry Incidence (epidemiology) nutritional and metabolic diseases medicine.disease Obesity digestive system diseases Liver biopsy medicine.symptom Steatosis business |
| Zdroj: | The American Journal of Gastroenterology. 98:500-500 |
| ISSN: | 1572-0241 0002-9270 |
| DOI: | 10.1111/j.1572-0241.2003.07278.x |
| Popis: | The incidence of obesity in the western population in recent decades has grown enormously. Study estimates suggest that 15–20% of the U.S. population is obese (BMI ≥ 30kg/m2) (1, 2). As a consequence, concern for a possible impending epidemic of nonalcoholic fatty liver disease (NAFLD) has also risen. NAFLD has a broad pathologic spectrum which ranges from nonalcoholic steatohepatitis or NASH (probably a precursor to cirrhosis) to simple fatty infiltration of the liver or steatosis (a relatively benign liver condition). In an obese patient, with or without abnormal liver enzymes, there is currently no single laboratory or imaging test which can accurately separate steatosis from NASH. Recently, however, researchers from the University of Melbourne, Australia have proposed a relatively simple scoring system to aid in determining who among the severely obese (BMI ≥ 35kg/m2), are at risk for NASH and should be singled out for liver biopsy. The HAIR score combines the presence of hypertension (diagnosed by standard technique), elevated ALT (>40 IU), and Insulin Resistance index (>5.0) as a simple sum. Each component of the HAIR score is equally weighted and assigned a value of one. A severely obese, hypertensive patient whose insulin resistance index is |
| Databáze: | OpenAIRE |
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